Ambroise Desfosses

This study identifies distinct determinants of ACKR1 recognition by bacterial toxins, revealing a two-step mechanism involving sulfotyrosine binding and extracellular vestibule interaction.

The paper identifies a histidine switch that regulates pH-responsive self-assembly of a helical protein filament through electrostatic interactions.

This study determines the structural basis of Arf1-driven membrane tubulation using cryo-EM, revealing how Arf1 forms curved tubules and accommodates cargo.

This study identifies R27 methylation as a regulator of HRSV nucleocapsid structure and replication through molecular dynamics and cryo-EM analyses.

This study uses cryo-EM to determine the structure of LPOR-Chlide complexes, revealing a novel photocatalytic mechanism and structural basis for membrane remodeling.

This study identifies TTLL11 as a polyglutamylase that extends primary tubulin chains, revealing a new mechanism in the tubulin code and its interaction with other tubulin modifications.

This study identifies a histidine switch in C9CARD that regulates pH-dependent filament formation through electrostatic interactions and structural changes.

This study reveals the structural mechanism of MCIA complex assembly, showing how ECSIT and ACAD9 interact to facilitate Complex I biogenesis and links ECSIT phosphorylation to Alzheimer's disease pathology.

This paper investigates the acid-stress response of E. coli LdcI using cryo-EM and super-resolution imaging, revealing its supramolecular assembly and proposing a mechanistic model for its function.