SPATNIC enables H&E-grounded cancer-cell identification across spatial and single-cell transcriptomic modalities in colorectal cancer
Shunsuke A. Sakai, Ryosuke Nomura, Masaki Ohira…·Riu Yamashita
SPATNIC is a variational autoencoder that identifies cancer cells from spatial and single-cell transcriptomic data in colorectal cancer, outperforming existing tools and identifying a rare cancer stem cell population.