Martin Gerbert Frasch

Fetal Twin: a mechanistic computational model of fetal physiology for heart-rate-variability biomarker research

This paper introduces Fetal Twin, a mechanistic computational model of fetal physiology to study heart-rate-variability biomarkers, revealing artifacts in beat detection and fidelity requirements for accurate biomarker interpretation.

Coordination-dynamics invariants from simultaneous vagus nerve electroneurogram and ECG: a Python pipeline applied to neonatal piglet endotoxaemia

The paper introduces a Python pipeline to extract coordination-dynamics invariants from simultaneous VENG and ECG data in neonatal piglets, revealing state-switching patterns and coupling between phase coherence and HRV scaling exponents during endotoxaemia.

Maternal prenatal stress induces sex-dependent changes in tRNA fragment families and cholinergic pathways in newborns

The paper shows maternal prenatal stress causes sex-dependent changes in tRNA fragments and cholinergic pathways in newborns.

A Doubly Stochastic Change Point Detection Algorithm for Noisy Biological Signals

The paper introduces a change point detection algorithm for noisy biological time series, showing improved performance over existing methods.

α7 nicotinic acetylcholine receptor signaling modulates the inflammatory and iron homeostasis in fetal brain microglia

This study shows that 7nAChR agonists reverse LPS-induced pro-inflammatory microglial phenotype in fetal sheep, while antagonists enhance it, suggesting therapeutic potential for neuroinflammation.