Human brain microRNAs exhibit cell-type specificity and agedependence
Serafima Dubnov, Lihen Laski, Ido Zchut…·Hermona Soreq
The paper profiles microRNA expression in human brain cell types to reveal cell-type specificity and age-related changes.
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Hebrew University of JerusalemORCID 0000-0001-8959-8640Unclaimed ORCID profile · follow to get notified of new preprints
9 papers
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Serafima Dubnov, Lihen Laski, Ido Zchut…·Hermona Soreq
The paper profiles microRNA expression in human brain cell types to reveal cell-type specificity and age-related changes.
Shani Vaknine, Silvia Martina Lobmaier, Ritika Sharma…·Hermona Soreq
The paper shows maternal prenatal stress causes sex-dependent changes in tRNA fragments and cholinergic pathways in newborns.
Serafima Dubnov, Estelle R. Bennett, Nadav Yayon…·Hermona Soreq
This study shows that Klotho knockout affects brain microRNAs and tRNA fragments linked to aging and Alzheimer's disease in both mice and humans.
Yonat Tzur, Serafima Dubnov, Nimrod Madrer…·Hermona Soreq
This study identifies RPL24 as a regulator of miR processing and tRF production, showing its interaction with DDX5 and its effect on miR levels and tRF profiles in human and plant cells.
Yonat Tzur, Katarzyna Winek, Nimrod Madrer…·Hermona Soreq
This study identifies LysTTT-5tRF and miR-194-5p as co-regulators of hepatic steatosis through beta-Klotho and Perilipin 2, showing their cooperative roles in lipid metabolism.
Dana Shulman, Serafima Dubnov, Tamara Zorbaz…·Hermona Soreq
The paper identifies sex-specific changes in cholinergic-targeting tRNA fragments in Alzheimer's disease, linking them to cholinergic neuron loss and dementia.
Iddo Paldor, Nimrod Madrer, Shani Vaknine…·Hermona Soreq
The paper examines tRF levels in CSF and blood across age, sex, and Parkinson's disease, finding distinct patterns and suggesting their potential as biomarkers.
William C. Shropshire, Anna Konovalova, Patrick M. McDaneld…·SA Shelburne
This study identifies mobile genetic elements driving β-lactamase gene amplification in non-CP-CRE bloodstream infections through genomic analysis.
Yu‐Chih Tsai, David Greenberg, James Powell…·Tyson A. Clark
Combining amplification-free CRISPR-Cas9 targeted enrichment with Single Molecule, Real-Time (SMRT) long-read sequencing captures and sequences human repeat-expansion disease loci across HTT, FMR1, C9orf72, and ATXN10 without PCR bias.