Jack Perry Antel

Remodeling oligodendrocyte lipid metabolism via liver X receptors overcomes inflammatory blockade of remyelination

This study shows that inflammation disrupts oligodendrocyte precursor cell lipid metabolism, impairing remyelination, and that activating liver X receptors can restore lipid balance and promote myelin repair.

Age and maturation stage linked consequences of fibrinogen on human oligodendroglia

This study shows fibrinogen has opposing effects on human oligodendrocyte lineage cells depending on their maturation stage, inhibiting early differentiation but enhancing myelination in mature cells.

Epigenomic regulation of human oligodendrocyte myelination properties, relation to age and lineage

The paper investigates how epigenomic factors like chromatin accessibility and histone modifications affect human oligodendrocyte myelination and age-related vulnerability to injury.

Dendritic Polyglycerol Amine Substrate Extends the Viability of Mixed Glial Cultures for Repeated Isolation of Immature Oligodendrocyte Lineage Cells

This study shows that dPGA-coated substrates support longer-term mixed glial cultures, enabling repeated isolation of immature oligodendrocyte lineage cells compared to PDL-coated substrates.

Detection of astrocyte epigenetic memory in in vitro systems, experimental autoimmune encephalomyelitis and multiple sclerosis samples

The paper rebuts claims that astrocyte epigenetic memory is due to immune cell contamination, showing its existence in pure astrocyte cultures and MS samples.

Pro-Inflammatory Molecules Implicated in Multiple Sclerosis Divert the Development of Human Oligodendrocyte Lineage Cells

This study shows that TNF and IFNγ inhibit human OPC differentiation into oligodendrocytes and promote an astrocyte-like reactive phenotype, potentially contributing to impaired myelin repair in MS.

Single Cell RNAseq to identify subpopulations of glial progenitors in iPSC-derived oligodendroglial lineage cultures

The paper uses single-cell RNA sequencing to identify subpopulations of glial progenitors in iPSC-derived oligodendroglial lineage cultures and characterizes their differentiation response.

A subset of human choroid plexus epithelial cells exhibit mitochondrial eccentricity and distinct expression of the pigmentation-associated enzyme TYRP1

The paper identifies four subpopulations of human choroid plexus epithelial cells, including TYRP1-high cells with distinct molecular features related to pigmentation, cell cycling, and stress.

Uncovering immune characteristics of neurons in the context of multiple sclerosis and experimental autoimmune encephalomyelitis

This study identifies immune gene expression signatures in neurons from MS patients and EAE mice, revealing shared pathways and potential roles for IRF5 and STAT1 in neuronal inflammation.

Identity and Nature of Neural Stem Cells in the Adult Human Subventricular Zone

This study creates a cell atlas of the adult human subventricular zone using single-cell transcriptomics, identifying multipotent neural stem cells and their lineage potential.

An adapted stem cell-derived microglia protocol for the study of microgliopathies and other neurological disorders

The paper optimizes an iMGL protocol to generate microglia-like cells from an ALSP patient, revealing functional defects in migration and phagocytosis.

Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases

The paper shows TSPO expression increases in activated microglia in rodent models but not in human neurodegenerative diseases, indicating species-specific differences in TSPO function.

Systematic comparison of culture media uncovers phenotypic shift of human microglia defined by reduced reliance to CSF1R signaling

The paper compares culture media effects on human microglia, finding that serum supports key genes and phagocytic function, while CSF1R signaling reliance decreases in culture.

Multiple sclerosis iPSC-derived oligodendroglia conserve their intrinsic properties to functionally interact with axons and glia in vivo

The paper shows MS-derived oligodendroglia can myelinate axons and form functional connections in a mouse model, suggesting the differentiation block is due to environmental factors, not intrinsic deficits.

RNA-binding protein altered expression and mislocalization in multiple sclerosis

The paper investigates altered expression and mislocalization of RNA-binding proteins TDP-43 and PTB in multiple sclerosis lesions and cultured oligodendrocytes, linking them to demyelination and neurodegeneration.

Deep Learning for High-Throughput Quantification of Oligodendrocyte Ensheathment at Single-Cell Resolution

This paper develops a deep learning method to quantify oligodendrocyte ensheathment in vitro, achieving accuracy comparable to human experts and enabling high-throughput analysis.

α7 nicotinic acetylcholine receptor signaling modulates the inflammatory and iron homeostasis in fetal brain microglia

This study shows that 7nAChR agonists reverse LPS-induced pro-inflammatory microglial phenotype in fetal sheep, while antagonists enhance it, suggesting therapeutic potential for neuroinflammation.