Leslie C. Griffith

The paper investigates sex-specific regulation of CaMKII in Drosophila, showing differences in steady-state and activity-dependent levels between males and females without affecting plasticity.

This study shows that neuronal activity drives local CaMKII synthesis and localization via autophosphorylation-dependent pathways, leading to spatially and functionally distinct CaMKII populations.

The paper develops genetically-encoded markers for visualizing single dense core vesicles using confocal microscopy, improving resolution over traditional methods.

The paper shows that disrupting activity in specific dopaminergic neurons during memory consolidation impairs long-term memory and causes sleep fragmentation in Drosophila.

The paper shows miR-190 suppresses cholinergic co-transmission in glutamatergic and GABAergic neurons by posttranscriptional regulation, affecting sleep behavior.

The paper identifies subtype-specific roles of ellipsoid body ring neurons in sleep regulation in Drosophila using thermogenetic screens and statistical models.

The paper shows that local axonal translation of CaMKII mRNA, mediated by Mub and a 3UTR element, is essential for asymmetric CaMKII distribution and associative memory in Drosophila neurons.

This paper develops an ex vivo Drosophila brain model that recapitulates pairing-dependent plasticity in the mushroom body, showing it is input-specific and requires CaMKII and sleep.

This study shows that rest, not sleep, is required for Drosophila to learn a sucrose-reinforced operant task, and identifies a role for cAMP in learning.

This study identifies bantam as a regulator of sleep in Drosophila by inhibiting specific wake-promoting neurons during the night.

This study shows that Pigment-dispersing factor (PDF) signaling is essential for olfactory associative memory in Drosophila, with distinct effects on appetitive and aversive memory based on circadian timing.

The paper introduces a method to measure sleep pressure and depth in Drosophila using movement data without disrupting behavior, showing these parameters are independent and influence total sleep.

This study shows that Ca2+/CaM inhibition of Drosophila EAG channels regulates presynaptic excitability and memory formation.