Matthew J. Hilton

This study identifies non-myogenic mesenchymal cells as contributors to rotator cuff tear fibrosis and myosteatosis and shows that targeting RET signaling can reduce fat infiltration.

The paper shows hypertrophic chondrocytes dedifferentiate into marrow-associated stem/progenitor cells that contribute to osteoblasts, adipocytes, and bone marrow establishment during skeletal development.

The paper identifies HES1 as a critical mediator of the SHH-GLI3 axis in regulating digit number, showing its role in inducing polydactyly and modulating cell proliferation and chondrogenesis.

This study identifies ADGRG6 as a regulator of intervertebral disc homeostasis through STAT3 signaling, showing that inhibiting STAT3 reduces disc degeneration in a mouse model.