Zhaoyang Liu

The paper identifies a genetic interaction between Adgrg6 and Sox9 that contributes to spinal stability and AIS-like pathology in mice.

This study identifies PRMT1-SFPQ as a regulator of intron retention in craniofacial development, leading to reduced matrix gene expression through NMD.

This study compares the biological and biomechanical features of mandibular condylar cartilage and articular cartilage in mice, revealing distinct structural and functional differences.

The paper identifies a novel SOX9 variant in the TAM domain linked to axial skeletal dysplasia and scoliosis, showing reduced protein stability and recapitulating human phenotypes in mice.

This study shows that ADGRG6 is essential for postnatal growth plate homeostasis in mice, affecting chondrocyte survival, proliferation, and differentiation.

This study identifies Adgrg6 as essential for maintaining spine alignment by regulating biomechanical properties and gene expression in connective tissues, offering therapeutic insights for adolescent idiopathic scoliosis.

This study identifies AIS-associated genes and regulatory elements through RNA-seq and ChIP-seq in human and mouse tissues, revealing pathways involved in chondrogenesis and connective tissue maintenance.

This study shows PRMT5 regulates terminal hypertrophic chondrocyte differentiation and models infantile idiopathic scoliosis in mice.

This study identifies ADGRG6 as a regulator of intervertebral disc homeostasis through STAT3 signaling, showing that inhibiting STAT3 reduces disc degeneration in a mouse model.