Courtney M. Karner

This study shows that glutathione is essential for proteostasis in hematopoietic stem cells but not for ferroptosis prevention.

This study shows that N-acetylcarnosine treatment improves survival and delays age-related decline in multiple organ systems in female mice.

The paper shows proteolytic cleavage of fatty acid synthase (FASN) activates a global signal for stress resolution, promoting an anti-inflammatory profile and down-regulating stress-responsiveness.

The paper identifies SLC38A2 as essential for proline supply during osteoblast differentiation and bone formation, showing its role in proline-rich protein synthesis.

The paper shows hypertrophic chondrocytes dedifferentiate into marrow-associated stem/progenitor cells that contribute to osteoblasts, adipocytes, and bone marrow establishment during skeletal development.

This study identifies Slc1a5 as essential for osteoblast differentiation and bone development by facilitating glutamine and asparagine import in mice.

This study identifies Adgrg6 as essential for maintaining spine alignment by regulating biomechanical properties and gene expression in connective tissues, offering therapeutic insights for adolescent idiopathic scoliosis.

The paper identifies HES1 as a critical mediator of the SHH-GLI3 axis in regulating digit number, showing its role in inducing polydactyly and modulating cell proliferation and chondrogenesis.

The paper identifies Fzd5, Lrp6, and Rspon1 as critical components required for WNT9b responsiveness in nephron progenitor cells.