Latent Regulatory Programs Generate Synthetic T Cell States with Enhanced Therapeutic Potential
Brandon M. Pratt, Genevieve Nicole Mullins, Nolan James Brown, William D. Green, Jennifer L. Modliszewski, Fucong Xie, Lara van Rooyen, Vasyl Zhabotynsky, Alexander N. Jambor, Gabrielle Heather Cannon, Jarred Michael Green, Andrew S. Kennedy, Coral del Mar Alicea Pauneto, Huitong Shi, Emily F. Merritt, , J. Justin Milner
The paper uses in vivo single-cell gain-of-function screening to identify latent transcriptional programs that reprogram T cells into synthetic states with enhanced therapeutic potential.
bioRxiv · Jan 8, 2026 · PreprintImmunology