J. Justin Milner

Optimal transport fate mapping resolves T cell differentiation dynamics across tissues

This paper uses optimal transport to map CD8 T cell differentiation across time and tissues, revealing distinct migration waves and gene regulatory programs.

Latent Regulatory Programs Generate Synthetic T Cell States with Enhanced Therapeutic Potential

The paper uses in vivo single-cell gain-of-function screening to identify latent transcriptional programs that reprogram T cells into synthetic states with enhanced therapeutic potential.

An injectable chitosan hydrogel localizes and tunably releases immunotherapeutics intratumorally eliminating both treated and abscopal murine triple negative breast tumors

This paper demonstrates that XCSgel, an injectable hydrogel, can localize and release immunotherapeutics to eliminate primary and abscopal murine triple-negative breast tumors with a single injection.

Feature selection for preserving biological trajectories in single-cell data

This paper introduces DELVE, a feature selection method that improves trajectory inference by identifying dynamically expressed features that better represent biological processes in single-cell data.