Author

Sylvia Erhardt

Karlsruhe Institute of TechnologyORCID 0000-0003-3169-241XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Developmental Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:statistical model· 2 Approach:deep learning· 1 Research Focus:differential expression· 1 Organism:Drosophila· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

Abhik Ghosh MoulickiD· 1 shared Agnieszka PancholiiD· 1 shared Alexander M. SimoniD· 1 shared Ana BanitoiD· 1 shared Carmelo FerraiiD· 1 shared Elisa Kämmer· 1 shared Irina WachteriD· 1 shared J. BöhmiD· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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1 shared paperBiophysics

Abhik Ghosh MoulickORCID

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3 papers

Recent·Most cited

BiophysicsNanoscalePeer-reviewedJan 1, 2026

Structural dynamics in the CENP-A nucleosome impacted by protein-protein interactions with centromere protein N

Abhik Ghosh Moulick, Sylvia Erhardt, Wolfgang Wenzel, Mariana Kozłowska

This study uses molecular dynamics simulations to analyze how CENP-N interacts with CENP-A nucleosomes, revealing structural changes and their impact on conformational states and protein interactions.

1 citation

structural biologydeep learning

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Developmental BiologybioRxivPreprintJul 4, 2023

Transcriptional clusters follow a conserved condensation-dispersal sequence during stem cell differentiation

Tim Klingberg, Irina Wachter, Agnieszka Pancholi…·Lennart Hilbert

The paper shows that Pol II transcriptional clusters undergo a conserved condensation-dispersal sequence during stem cell differentiation across species.

4 citations

mouseDrosophila

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Molecular BiologybioRxivPreprintMar 15, 2023

The bromodomain inhibitor JQ1 is a molecular glue targeting centromeres

Samuel Corless, Noor Pratap-Singh, Nezha S. Benabdallah…·Sylvia Erhardt

The paper identifies JQ1 as a molecular glue that targets centromeres by stabilizing BRD4-CENP-B interactions, enhancing centromere cohesion and affecting cell proliferation.

5 citations

humanproteomics

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