Author

Si-Yang Zheng

Carnegie Mellon University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 3 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 3 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Abbas Jalili· 2 shared Sheng ZhangiD· 2 shared Abigail SullivaniD· 1 shared Adithri Pingali· 1 shared Audrey Lawrence· 1 shared August KohlsiD· 1 shared Barbie Varghese· 1 shared Carl EngmaniD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersBioengineering

Abbas Jalili

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Interstitium-mimicking porous alveolar membranes enable physiologic aerosol transport and distinct acute-chronic lung injury responses

Jae‐Won Choi, Sheng Zhang, Abbas Jalili, August Kohls, Woo‐Youl Maeng, Sikandar Azam, Wu Liu, Barbie Varghese, Yixin Zhao, Xi Ren, Shimin Liu, Si-Yang Zheng

This paper develops an interstitium-mimicking alveolar membrane for lung-on-chip systems that enables physiologic aerosol transport and reveals distinct acute-chronic lung injury responses.

Advanced Functional Materials · Jul 10, 2026Peer-reviewedBioengineering

Droplet-compatible single-cell DNA methylation sequencing with PreTIC

Sheng Zhang, Faming Wang, Y Zhang, Keng-Jung Lee, Carl Engman, Hong-Zhang He, Yong Fan, Si-Yang Zheng

The paper introduces PreTIC, a method for single-cell DNA methylation sequencing compatible with droplet microfluidics, and demonstrates its ability to generate over 13,000 methylomes from human cells.

bioRxiv · Jun 21, 2026 · PreprintGenomics

Membrane-Free Alveolus-on-a-Chip via Biodegradable Scaffold Recapitulates Interstitial Mechanics, Immune Trafficking, and Aerosolized mRNA Delivery

Jaewon Choi, Huy Hoang Nguyen, Abbas Jalili, Matthew Andersen, Si-Yang Zheng

This paper introduces a membrane-free alveoli-on-a-chip using biodegradable scaffolds that mimics interstitial mechanics, immune trafficking, and aerosolized mRNA delivery in human alveoli.

bioRxiv · Apr 19, 2026 · PreprintBioengineering

Mitochondria-containing large extracellular vesicles target mouse motor neurons upon intramuscular injection

Paromita Paul Pinky, Zhong-Min Wang, Purva Khare, Jhanvi R Jhaveri, Abigail Sullivan, Vivek Basudkar, Krithika Rao, Audrey Lawrence, Adithri Pingali, Kandarp M. Dave, Donna Beer Stolz, Ming Sun, Si-yang Zheng, Sruti S. Shiva, Carol Milligan, , Devika Soundara Manickam

This study shows that mitochondria-containing large extracellular vesicles (lEVs) improve mitochondrial function in heat-stressed neurons and deliver mitochondria to motor neurons in vivo.

Extracellular Vesicle · Dec 24, 2025Peer-reviewedBioengineering