Kyoung Tai No

This study reports cryo-EM structures of two small protein-ligand complexes near the theoretical size limit of 38 kDa, demonstrating cryo-EM's utility for structure determination and drug screening.

This study identifies a noncanonical role of TEAD in DNA repair, showing it can be targeted to overcome chemoresistance in tumors.

This study introduces CM-SLP, a platform to identify non-oncology drugs that enhance cancer cell death under altered nutrient conditions by targeting metabolic vulnerabilities.

This paper determines cryo-EM structures of an anti-MLC1 Fab in apo and peptide-bound states, revealing the structural basis of antigen recognition and demonstrating cryo-EM's capability for small Fab-antigen complexes.

This paper introduces GENiPPI, a molecular generative framework for PPI interfaces, which generates novel compounds targeting PPIs and demonstrates its effectiveness in capturing interface-molecule relationships.

This study uses a transformer-based generative model to generate novel protein-protein complex conformations from molecular dynamics simulations, enhancing conformational exploration.

The paper introduces ACGDC, a deep learning model that generates synthetic single-cell multi-omics samples to aid in brain disease research.

PhyloSophos maps scientific names to reference databases using taxonomic rules, improving data processing for biodiversity and ethnopharmacological resources.