Kunwoong Park

High-resolution cryo-EM structures of small protein-ligand complexes near the theoretical size limit

This study reports cryo-EM structures of two small protein-ligand complexes near the theoretical size limit of 38 kDa, demonstrating cryo-EM's utility for structure determination and drug screening.

Structural insights into autophosphorylation-mediated heat shock response by the protein-arginine kinase McsAB

This study reveals the structural mechanism of McsAB-mediated suppression of CtsR during heat shock, showing autophosphorylation is essential for rapid response.

Cryo-EM structures of an anti-MLC1 Fab in apo and peptide-bound states reveal the structural basis of antigen recognition

This paper determines cryo-EM structures of an anti-MLC1 Fab in apo and peptide-bound states, revealing the structural basis of antigen recognition and demonstrating cryo-EM's capability for small Fab-antigen complexes.

Structural analyses of gibberellin-mediated DELLA protein degradation

The paper presents cryo-EM structures of Arabidopsis DELLA protein RGA bound to GID1A and GID1A-SLY1-ASK2, revealing how gibberellin promotes DELLA degradation through complex assembly.