Author

Léa Mallo

Inserm

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Alessandra BalduiniiD· 1 shared Alexandra MazharianiD· 1 shared Alicia BornertiD· 1 shared Alma MånssoniD· 1 shared Anita E. EcklyiD· 1 shared Catherine LéoniD· 1 shared Catherine StrasseliD· 1 shared Cécile Loubière· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperCell Biology

Alessandra BalduiniORCID

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2 papers

Recent·Most cited

CRISPR/Cas9-mediated deletion of Shp1 and Shp2 reveals distinct roles in human megakaryopoiesis and proplatelet formation

Eugénie Schaeffer, Elsa Barré, Desline Hennequin, Cécile Loubière, Léa Mallo, Catherine Strassel, Christian Andrea Di Buduo, Alessandra Balduini, Yotis A. Senis, Alexandra Mazharian

This study uses CRISPR/Cas9 to delete Shp1 and Shp2 in human CD34+ cells, showing Shp2 is critical for megakaryopoiesis and thrombopoiesis while Shp1 is not.

bioRxiv · Jul 24, 2026 · PreprintCell Biology

Megakaryocytes assemble a three-dimensional cage of extracellular matrix that controls their maturation and anchoring to the vascular niche

Claire Masson, Cyril Scandola, Jean‐Yves Rinckel, Fabienne Proamer, Emily Janus‐Bell, Fareeha Batool, Naël Osmani, Jacky G. Goetz, Léa Mallo, Nathalie Brouard, Catherine Léon, Alicia Bornert, Renaud Poincloux, Olivier Destaing, Alma Månsson, , Anita E. Eckly

This paper identifies a three-dimensional extracellular matrix cage formed by laminin and collagen IV that anchors megakaryocytes in the bone marrow and regulates their maturation and intravasation.

bioRxiv · Sep 30, 2024Physiology