Author

Bahaa Al-mhanawi

The University of QueenslandORCID 0000-0002-7425-3364Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Microbiology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Ernst Jurgen WolvetangiD· 3 shared Mohammed R. ShakeriD· 3 shared Sean D. MorrisoniD· 3 shared Julian D. J. SngiD· 2 shared Alexander A. KhromykhiD· 1 shared Andrii SlonchakiD· 1 shared Anja KipariD· 1 shared Giuseppe BalistreriiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersCell Biology

Ernst Jurgen WolvetangORCID

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3 papers

Recent·Most cited

Oligodendrocyte Enriched Brain Organoids Reveal Impaired Oligodendroglial Maturation and Altered Neural Network Activity in Down Syndrome

Marta Boira Marti, Sean D. Morrison, Selin Pars, Bahaa Al-mhanawi, Peter G. Noakes, Ernst Jurgen Wolvetang, Mohammed R. Shaker

This study uses brain organoids to show trisomy 21 impairs oligodendrocyte maturation and neural network function in Down syndrome.

bioRxiv · Aug 28, 2026 · PreprintCell Biology

SARS-CoV-2 infection in hiPSC-derived neurons is cathepsin-dependent and causes accumulation of HIF1alpha and phosphorylated tau

Pinja Kettunen, Janika Ruuska, Tania Quirin, Ravi Ojha, Saber H. Saber, Julian D. J. Sng, Sean D. Morrison, Bahaa Al-mhanawi, Mohammed R. Shaker, Simon De Neck, Anja Kipar, Lassi Paavolainen, Ernst Jurgen Wolvetang, Merja Joensuu, Jari Koıstınaho, , Giuseppe Balistreri

This study shows SARS-CoV-2 infects hiPSC-derived neurons via endosomal-lysosomal pathway dependent on cathepsins, leading to HIF1alpha accumulation and phosphorylated tau, suggesting neurodegenerative effects.

Molecular Therapy — Nucleic Acids · Oct 1, 2025Peer-reviewedMicrobiology

Choroid plexus defects in Down syndrome brain organoids enhance neurotropism of SARS-CoV-2

Mohammed R. Shaker, Andrii Slonchak, Bahaa Al-mhanawi, Sean D. Morrison, Julian D. J. Sng, Justin John Cooper-White, Alexander A. Khromykh, Ernst Jurgen Wolvetang

This study shows that Down syndrome brain organoids with choroid plexus defects enhance SARS-CoV-2 neurotropism, which can be inhibited by targeting TMPRSS2 and Furin.

Science Advances · Jun 5, 2024Peer-reviewedNeuroscience