Murat Açar

The paper quantifies a 23.4% decline in single-strand annealing repair efficiency in old cells, linked to prolonged G1-phase duration and high heteroduplex rejection.

The paper models aging cells to show that damage accumulation and repair rates are key to fitness and clonal senescence, while division asymmetry has minimal impact.

This study shows that inhibiting GMP synthesis extends yeast replicative lifespan through a mechanism independent of known nutrient-sensing and sirtuin pathways.