Sergio A. Hassan

The paper develops a rule-based model of TLR4 signaling in mouse macrophages, identifies a missing negative feedback checkpoint involving TANK and IKKε, and validates its role in restraining inflammation.

The paper introduces a computational framework to identify antimicrobial targets by analyzing protein dynamics, showing that few protein-level mechanisms account for most antimicrobial effects.

The paper investigates how mutations in SARS-CoV-2 N protein affect RNP formation and stability, finding convergent evolution and enhanced RNP assembly in Omicron variants.

The paper identifies short, epigenetic centromeres in Pneumocystis species using ChIP-Seq and shows they differ from S. pombe centromeres despite evolutionary proximity.