Haruka Chino

This study identifies RNF185 as a human ER-resident ubiquitin ligase that destabilizes membrane proteins with distinct aberrancies across all three ERAD branches.

The paper reports cryo-EM structures of two human SPFH protein complexes, revealing their stoichiometry and architectural features.

The paper reports the cryo-EM structure of TXNL1-bound proteasome and identifies interactions critical for stress-induced degradation of TXNL1.