Christopher Nardone

The paper identifies activation and inactivation pathways of Mga2, a p53-like transcription factor in yeast, showing its role in lipid homeostasis through regulation of Ole1 expression.

The paper reports the cryo-EM structure of TXNL1-bound proteasome and identifies interactions critical for stress-induced degradation of TXNL1.

This study reveals the structural basis of the midnolin-proteasome pathway and shows that midnolin downregulation promotes myeloma cell survival by enhancing IRF4 expression.

This paper describes a novel RNA splicing system, SOS splicing, that removes transposons from mRNAs in C. elegans and human cells, protecting genes from TE-mediated disruption.