Matthew C. J. Yip

ZNFX1, an immunoregulatory RNA helicase and E3 ubiquitin ligase, assembles into pleiomorphic polymers

This study identifies ZNFX1 as a multifunctional enzyme in innate immunity that couples RNA sensing to ubiquitin signaling and assembles into higher-order structures for signal amplification.

Structure of the TXNL1-bound proteasome

The paper reports the cryo-EM structure of TXNL1-bound proteasome and identifies interactions critical for stress-induced degradation of TXNL1.

Structural basis for the midnolin-proteasome pathway and its role in suppressing myeloma

This study reveals the structural basis of the midnolin-proteasome pathway and shows that midnolin downregulation promotes myeloma cell survival by enhancing IRF4 expression.

Recognition of phylogenetically diverse pathogens through enzymatically amplified recruitment of RNF213

This study identifies how RNF213 recognizes diverse pathogens through enzymatic amplification of cooperative recruitment.