Sichen Shao

This study identifies RNF185 as a human ER-resident ubiquitin ligase that destabilizes membrane proteins with distinct aberrancies across all three ERAD branches.

The paper investigates how mitochondrial translational activators (TAs) facilitate transcript-specific translation initiation by aligning mRNAs at the small mitoribosomal subunit.

The paper reports cryo-EM structures of two human SPFH protein complexes, revealing their stoichiometry and architectural features.

The paper reports the cryo-EM structure of TXNL1-bound proteasome and identifies interactions critical for stress-induced degradation of TXNL1.

This study reveals the structural basis of the midnolin-proteasome pathway and shows that midnolin downregulation promotes myeloma cell survival by enhancing IRF4 expression.

This study identifies how CDAN1 inhibits ASF1A/B chaperone function through structural and biochemical analysis of CDAN1 complexes.