Eric N. Chiles

This paper identifies IMPDH as a therapeutic target in PTEN-deficient T-ALL, showing IMPDH inhibitors selectively kill these cells and extend survival in mouse models.

This study shows that bioenergetic stress from antibiotic treatment enhances antimicrobial resistance and persistence in E. coli through increased ROS, repair mechanisms, and stringent response activation.

This study shows coral larvae maintain carbon provisioning from algal symbionts under heat stress by sequestering nitrogen into dipeptides, reducing symbiont growth but preserving photosynthesis and carbon transfer.

This study characterizes the thermal stress response in Montipora capitata using transcriptomic and metabolomic data, revealing key gene and metabolite changes associated with stress.