Author

Thu Le Le

Rutgers, The State University of New Jersey

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:mouse· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Alexander J. ValvezaniD· 1 shared Daniel HerranziD· 1 shared Emily Hyde· 1 shared Eric N. ChilesiD· 1 shared Kelly Mulraney· 1 shared Maria Rubio· 1 shared Namratha SheshadriiD· 1 shared Rayees Ahmad PadderiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Alexander J. ValvezanORCID

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1 paper

Recent·Most cited

PTEN-loss confers dependence on the guanylate synthesis enzyme IMPDH in T-cell acute lymphoblastic leukemia

Rayees Ahmad Padder, Thu Le Le, Emily Hyde, Maria Rubio, Eric N. Chiles, Namratha Sheshadri, Kelly Mulraney, Wei Zong, Xiaoyang Su, Daniel Herranz, Alexander J. Valvezan

This paper identifies IMPDH as a therapeutic target in PTEN-deficient T-ALL, showing IMPDH inhibitors selectively kill these cells and extend survival in mouse models.

bioRxiv · Dec 24, 2025 · PreprintCancer Biology