Author

Leonardo Farias Serafim

Georgia State UniversityORCID 0000-0003-3354-7451Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1 Research Focus:variant effect prediction· 1 Organism:yeast· 1

Frequent Co-Authors

Ivaylo N. IvanoviD· 2 shared Andrew S. Arvai· 1 shared Anil K. Mantha· 1 shared Anita H. CorbettiD· 1 shared Bradley R. Kossmann· 1 shared Chunli YaniD· 1 shared David M. WilsoniD· 1 shared Dustin L. GableiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersGenetics

Ivaylo N. IvanovORCID

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2 papers

Recent·Most cited

GeneticsbioRxivPreprintAug 2, 2026

Systematic comparison of pathogenic variants of the RNA exosome gene EXOSC3/RRP40 in Saccharomyces cerevisiae reveals variant-specific functional consequences

Milo B. Fasken, Sara W. Leung, Leonardo Farias Serafim…·Anita H. Corbett

The paper systematically analyzes eight pathogenic EXOSC3 variants in yeast to determine their functional consequences on RNA exosome function.

DOI 10.64898/2026.07.29.741578

yeaststatistical model

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BiochemistrybioRxivPreprintMay 14, 2026

Orchestrated metal ion repositioning defines the dynamic catalytic strategy of the essential DNA repair nuclease APE1

Leonardo Farias Serafim, Susan Tsutakawa, Andrew S. Arvai…·Ivaylo N. Ivanov

This study reveals the dynamic catalytic mechanism of APE1 using a moving metal ion strategy, showing how Mg2+ repositioning enables efficient DNA repair without forming a pentavalent intermediate.

DOI 10.64898/2026.05.11.724140

humanstructural biology

𝕏 PostBluesky