Author

David M. Wilson

Hasselt UniversityORCID 0000-0002-8945-0395Unclaimed ORCID profile · follow to get notified of new preprints

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David M. Wilson1 paper

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Assay:proteomics· 1

Frequent Co-Authors

Afaf Helmy El-SagheeriD· 1 shared Andrea PierangeliniiD· 1 shared Andrew S. Arvai· 1 shared Anil K. Mantha· 1 shared Bennett Van HouteniD· 1 shared Bradley R. Kossmann· 1 shared Christopher John SchofieldiD· 1 shared Darragh Patrick O'BrieniD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiochemistry

Afaf Helmy El-SagheerORCID

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2 papers

Recent·Most cited

Orchestrated metal ion repositioning defines the dynamic catalytic strategy of the essential DNA repair nuclease APE1

Leonardo Farias Serafim, Susan Tsutakawa, Andrew S. Arvai, Bradley R. Kossmann, Anil K. Mantha, Rachel Abbotts, David M. Wilson, SANKAR P. MITRA, John A. Tainer, Ivaylo N. Ivanov

This study reveals the dynamic catalytic mechanism of APE1 using a moving metal ion strategy, showing how Mg2+ repositioning enables efficient DNA repair without forming a pentavalent intermediate.

bioRxiv · May 14, 2026 · PreprintBiochemistry

Molecular basis for CSB stimulation of the SNM1A DNA repair nuclease

Rebecca Roddan, Matthew A. Schaich, William J. Nathan, Iulia Kis, Andrea Pierangelini, Lucy R. Henderson, Raman van Wee, Louise Martin, Afaf Helmy El-Sagheer, Philipp Kukura, Tom P Brown, Darragh Patrick O'Brien, Joseph A. Newman, David M. Wilson, Christopher John Schofield, , Peter J. McHugh

This study identifies how CSB enhances SNM1A nuclease activity during ICL repair by interacting with its nuclease core and altering substrate conformation.

bioRxiv · Sep 5, 2024 · PreprintBiochemistry