Megan Culler Freeman

The paper investigates how mutations in EV-D68's VP1 and VP3 proteins affect neurotropism in human spinal cord organoids and links these findings to reduced neurovirulence observed after 2018.

This study develops a method to rescue B3 clade EV-D68 strains and shows they replicate more efficiently in spinal cord organoids than a neurovirulent B2 clade strain.

This study uses scRNA-seq to analyze EV-D68 infection in human spinal cord organoids, revealing strain-specific tropism and host transcriptional responses associated with AFM.

This study shows that immune cell infiltration into the spinal cord promotes paralysis in mice infected with EV-D68, suggesting immune cell targeting as a therapeutic strategy.