Terence S. Dermody

The paper shows that T cell fate differs based on antigen source and APC type, with distinct outcomes for dietary versus epithelial antigens.

The paper reports the cryo-EM structure of piscine orthoreovirus, showing structural conservation with mammalian orthoreoviruses despite low sequence identity.

This study uses high-resolution spatial transcriptomics to map viral tropism and immune responses in neonatal mouse brains infected with reovirus, revealing spatial patterns of infection and immune module organization.

This study shows that immune cell infiltration into the spinal cord promotes paralysis in mice infected with EV-D68, suggesting immune cell targeting as a therapeutic strategy.

This study shows a single amino acid change in a reovirus alters its infection outcome in mice with microbiota depletion, affecting tropism and sensitivity to microbiota-driven antiviral responses.

This study identifies Cmas and Slc35a1 as host factors required for reovirus binding and infection in murine microglial cells by mediating sialic acid expression.