Anna M. Krichevsky

Integrated single-cell profiling of RNA and DNA interactomes reveals targetable chromatin architectures in cancer

The paper introduces SCIENCE-seq, a single-cell interactomics platform that maps RNA-RNA and DNA-DNA interactions in cancer, identifying therapeutic targets through chromatin architectures.

tRNA-derived fragments elevated in Alzheimer's disease facilitate Tau aggregation

This study identifies tRNA-derived fragments (tRFs) as key regulators of Tau aggregation in Alzheimer's disease and shows their potential as therapeutic targets.

tRNA-derived fragments are elevated in the aging brain and may contribute to neurodegeneration

This study shows that tRNA-derived fragments (tRFs) accumulate in aging mouse brains and are elevated in human neurodegenerative conditions, suggesting a role in neurodegeneration.

Novel miRNA-inducing drugs enable differentiation of retinoic acid-resistant neuroblastoma cells

The paper identifies PP121 and bufalin as drugs that induce differentiation in retinoic acid-resistant neuroblastoma cells through miR-124 activation, maintaining differentiated states for over 16 weeks.

HOXDeRNA activates a cancerous transcription program and super-enhancers genome-wide

This study identifies HOXDeRNA as a long non-coding RNA that derepresses glioma-specific transcription factors by interacting with PRC2 and RNA quadruplex structures, driving astrocyte transformation into glioma-like cells.

Small Molecule Inducers of Neuroprotective miR-132 Identified by HTS-HTS in Human iPSC-derived Neurons

The paper identifies small molecule inducers of miR-132 in human iPSC-derived neurons using HTS-HTS, showing neuroprotective effects against neurodegenerative phenotypes.

A nuclear function for an oncogenic microRNA as a modulator of snRNA and splicing

The paper shows miR-10b interacts with U6 snRNA, altering splicing and affecting cell viability through changes in CDC42 isoforms and levels.

MicroRNA-132 provides neuroprotection for tauopathies via multiple signaling pathways

This study shows miR-132 protects neurons from tauopathy-related damage by regulating multiple pathways and reducing Tau pathology in mice.

Dissecting the role of non-coding RNAs in the accumulation of amyloid and tau neuropathologies in Alzheimer’s disease

The paper investigates the role of non-coding RNAs, specifically miRNAs and lincRNAs, in Alzheimer’s disease pathology by analyzing their expression in brain samples and integrating with mRNA data.