BiophysicsProceedings of the National Academy of SciencesPeer-reviewed
Proofreading and single-molecule sensitivity in T-cellreceptor signaling by condensate nucleation
William L. White, Hailemikael K. Yirdaw, Ariel J. Ben‐Sasson…·Hao Yuan Kueh
This paper shows that T-cell receptor signaling uses condensate nucleation to selectively detect single foreign peptides by amplifying weak signals and setting spatial-temporal thresholds.
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