Yoshihisa Nakahata

The paper develops sensitive FRET biosensors to visualize CaMKII activity dynamics in living cells and demonstrates their use in cultured and primary cells, including neurons and cardiomyocytes.

This study shows that KIF11 mutations impair microtubule dynamics and dendritic arborization in neurons, contributing to intellectual disabilities.

The paper investigates the molecular mechanisms of behavioral time scale plasticity (BTSP) in CA1 synapses, finding that delayed, dendritic, and stochastic CaMKII activation (DDSC) is essential for BTSP.

This study develops a low-cost, efficient method to generate floxed mice using CRISPR-Cas9 and in vitro fertilization, achieving a 10% success rate in 125 days with 16 mice.

The paper identifies an intronic lncRNA, ADEPTR, that is synaptically transported via cAMP/PKA and interacts with the Spectrin/Ankyrin network to regulate structural plasticity in hippocampal neurons.