Fuzheng Guo

This study identifies oligodendrocytes as the major source of SERPINA3N in ischemic stroke and shows that antagonizing it improves neurological outcomes.

This study identifies SerpinOLs as injury-responsive oligodendrocytes that modulate neuroinflammation and glial activation in both diseased and healthy CNS conditions.

This study challenges the role of SERPINA3N in neurodevelopment and injury, showing it does not enhance development but worsens injury and vascular damage.

This study investigates the role of Serpina3n in postnatal brain development and myelination, finding it dispensable under homeostatic conditions but involved in oxidative stress responses.

This study shows that PAK1 regulates OPC proliferation and repopulation, with mutations affecting oligodendroglial development and myelination.

This study identifies PARP1 as a key driver of oligodendrocyte differentiation and myelination, showing its role in both developmental and remyelination processes in the CNS.

This study shows TCF7l2 promotes oligodendrocyte differentiation by repressing autocrine BMP4 signaling, which is dysregulated in multiple sclerosis.

This study shows HIFα regulates developmental myelination in the CNS independently of autocrine Wnt signaling, identifying a HIF-Sox9 pathway in OPC differentiation.

This study shows that oligodendroglial HIF regulates CNS angiogenesis via VEGF-dependent signaling, independent of Wnt, and reveals a glial cell type-specific HIF-Wnt axis.