Control of OPC proliferation and repopulation by the intellectual disability gene PAK1 under homeostatic and demyelinating conditions
Yan Wang, Bokyung Kim, Shuaishuai Gong, Joohyun Park, Meina Zhu, Evelyn M. Wong, Audrey Y. Park, Jonathan Chernoff, Fuzheng Guo
This study shows that PAK1 regulates OPC proliferation and repopulation, with mutations affecting oligodendroglial development and myelination.
bioRxiv · Apr 26, 2024 · PreprintNeuroscience