Yan Wang

Dispensable regulation of brain development and myelination by the immune-related protein Serpina3n

This study investigates the role of Serpina3n in postnatal brain development and myelination, finding it dispensable under homeostatic conditions but involved in oxidative stress responses.

Role of PARP1 in oligodendrocyte differentiation during developmental myelination and remyelination after myelin damage

This study identifies PARP1 as a key driver of oligodendrocyte differentiation and myelination, showing its role in both developmental and remyelination processes in the CNS.

The Wnt effector TCF7l2 promotes oligodendroglial differentiation by repressing autocrine BMP4-mediated signaling

This study shows TCF7l2 promotes oligodendrocyte differentiation by repressing autocrine BMP4 signaling, which is dysregulated in multiple sclerosis.

HIFα regulates developmental myelination independent of autocrine Wnt signaling

This study shows HIFα regulates developmental myelination in the CNS independently of autocrine Wnt signaling, identifying a HIF-Sox9 pathway in OPC differentiation.

Glial type specific regulation of CNS angiogenesis by HIFα-activated different signaling pathways

This study shows that oligodendroglial HIF regulates CNS angiogenesis via VEGF-dependent signaling, independent of Wnt, and reveals a glial cell type-specific HIF-Wnt axis.