Bede P. Busby

The paper maps the functional importance of site-specific ubiquitination across the human proteome by analyzing conservation, perturbation, and machine learning scores.

The paper systematically maps the functional role of phosphorylation by analyzing phospho-deficient mutants in yeast and linking yeast phenotypes to human functional relevance.

The paper assesses how genetic background affects gene deletion phenotypes in yeast, finding significant variation across strains and conditions.

The paper benchmarks variant effect predictors and analyzes SNVs in H. sapiens, S. cerevisiae, and E. coli to predict molecular effects and generate protein complex burden scores.

The paper identifies master regulators of genetic interaction networks mediating statin response in yeast, showing variability across genetic backgrounds.