Mapping the functional importance of site-specific ubiquitination across the human proteome
Julian van Gerwen, Maximilian Fottner, Shengbo Wang, Bede P. Busby, Ellen Boswell, Paul Schnacke, Andrea C. Carrano, Malina A. Bakowski, Emily R. Troemel, Romain A. Studer, Marta Strumillo, Maria Jesus Martin, J. Wade Harper, Kathrin Lang, Andrew R. Jones, , Pedro Beltrão
The paper maps the functional importance of site-specific ubiquitination across the human proteome by analyzing conservation, perturbation, and machine learning scores.
bioRxiv · Oct 8, 2025 · PreprintCell Biology