André Mateus

This study examines mRNA-protein level correlations in bacterial pathogens under stress, finding reduced correlations and highlighting the role of post-translational modifications in stress adaptation.

The paper screens gut metabolites for anti-infective activity against Salmonella and Shigella, identifying indole derivatives with structure-activity relationships affecting virulence and growth.

The paper systematically profiles growth interactions among gut bacterial strains and identifies key species and mechanisms influencing microbial community dynamics.

This study uses vacuum-dried ATR-FTIR spectroscopy to analyze the structural features and HDX kinetics of GCN4, revealing distinct Amide I bands in dry samples.

NovoTax identifies prokaryotic strains from proteomics data without prior knowledge, achieving accurate species and strain identification and detecting contaminants.

This study identifies a non-catalytic role of METTL3 in regulating exocytosis and the cancer secretome through stabilization of EXOC7.

The paper identifies a VirB2-like protein in Gram-positive bacteria that forms pili essential for conjugation, challenging the previous belief that such pili are absent in these bacteria.

The paper uses thermal proteome profiling to study how glycosylation affects protein function and stability, finding that sialylation and fucosylation perturbations significantly impact cell surface protein interactions.

The paper shows that the pcnB gene in Shigella flexneri promotes virulence by sustaining optimal levels of the virulence plasmid pINV, enhancing colonization and infection.

The paper systematically characterizes transport regulation in E. coli across 94 chemical cues, revealing new transcriptional responses and the role of regulators like Rob.

This study identifies nitroxoline's broad antibacterial activity against Gram-negative bacteria, its mode of action involving metal homeostasis and outer membrane disruption, and resistance mechanisms across multiple species.

This study shows that Fibrillarin regulates oncogenic protein pools and ribosomal composition in triple-negative breast cancer by modulating rRNA methylation and RPS28 levels.

This study identifies the essential role of LD-transpeptidation in Agrobacterium tumefaciens cell wall integrity and growth by analyzing LDTs and their genetic interactions.

This study investigates how mechanical loading affects AMPK and mTOR signaling in myoblasts, showing that 10% static loading activates AMPK and inhibits mTOR, alters RNA/protein synthesis, and impacts mitochondrial biogenesis.

The paper identifies a microprotein from ATHB2 that regulates Arabidopsis growth and root development by modulating DNA-binding activity and light responses.

This study shows that LSD1's non-catalytic function regulates DNA methylation in mouse ESCs by controlling UHRF1 and DNMT1 stability through USP7 interaction.

The paper assesses the impact of phosphorylation on protein thermal stability using phospho-TPP in HeLa cells, finding that phosphorylation affects stability less than previously reported.

The paper develops a statistical method to analyze thermal proteome profiles and identifies off-target drug interactions in epigenetic drugs.

The paper systematically maps the functional role of phosphorylation by analyzing phospho-deficient mutants in yeast and linking yeast phenotypes to human functional relevance.

The paper creates a comprehensive human phosphoproteome by integrating 6,801 phospho-enriched mass spectrometry experiments and prioritizes functional phosphosites using machine learning.