Javier Cuitavi

This paper develops an intranasal liposomal NorBNI formulation that selectively delivers KOR antagonists to the brain, reducing systemic exposure and off-target effects while improving pain-induced negative affect.

This study shows that ketone bodies reduce brain energy metabolism disruption and prevent delirium-like cognitive deficits in aged mice during systemic inflammation.

This study investigates sex-dependent effects of inflammatory pain on negative affective states in rats and identifies kappa opioid receptor blockade in the nucleus accumbens shell as a potential intervention.