Ketone bodies mitigate against systemic inflammation-induced changes in brain energy metabolism and delirium-like deficits in aged mice
Pierre-Louis Hollier, M K Kirsten Chui, Javier Cuitavi, Paul Denver, Hugh J. Delaney, John C. Newman, Colm M. Cunningham
This study shows that ketone bodies reduce brain energy metabolism disruption and prevent delirium-like cognitive deficits in aged mice during systemic inflammation.
bioRxiv · Feb 1, 2026 · PreprintNeuroscience