Ryan J. McGinty

The paper analyzes the distribution of simple repeat lengths across mammalian genomes and shows that long repeats are abundant due to mutational dynamics, not natural selection.

This study shows that pathogenic (A2G3)n repeats in CANVAS stall DNA replication by forming alternative DNA structures like triplexes, while nonpathogenic (A4G)n repeats do not.

This paper creates a high-resolution transcriptomic and spatial cell type atlas of the whole adult mouse brain, revealing spatial organization and transcription factor codes for cell types.

The paper analyzes mutagenesis at non-B DNA motifs in the human genome, revealing biological mechanisms and correcting previous findings by accounting for confounding factors.

The paper decomposes mutation rate and spectra variation in human germline using blind source separation, identifying nine processes including those related to DNA damage and replication timing.