Pathogenic CANVAS (AAGGG)n repeats stall DNA replication due to the formation of alternative DNA structures
Julia A. Hisey, Elina A. Radchenko, Nicholas H Mandel…·Sergei M. Mirkin
This study shows that pathogenic (A2G3)n repeats in CANVAS stall DNA replication by forming alternative DNA structures like triplexes, while nonpathogenic (A4G)n repeats do not.