Author

Nicholas H Mandel

Tufts University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:DNA methylation· 1 Approach:experimental assay· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1 Assay:whole-genome sequencing· 1 Organism:yeast· 1

Frequent Co-Authors

Anastasia Rastokina· 2 shared Sergei M. MirkiniD· 2 shared Alfredo J. HernandeziD· 1 shared André NussenzweigiD· 1 shared C I Edvard Smith· 1 shared Chiara MasnovoiD· 1 shared Elina A. RadchenkoiD· 1 shared Gabriel E. Matos-RodriguesiD· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersGenetics

Anastasia Rastokina

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2 papers

Recent·Most cited

Pathogenic CANVAS (AAGGG)n repeats stall DNA replication due to the formation of alternative DNA structures

Julia A. Hisey, Elina A. Radchenko, Nicholas H Mandel, Ryan J. McGinty, Gabriel E. Matos-Rodrigues, Anastasia Rastokina, Chiara Masnovo, Silvia Ceschi, Alfredo J. Hernandez, André Nussenzweig, Sergei M. Mirkin

This study shows that pathogenic (A2G3)n repeats in CANVAS stall DNA replication by forming alternative DNA structures like triplexes, while nonpathogenic (A4G)n repeats do not.

Nucleic Acids Research · Feb 21, 2024Peer-reviewedGenetics

Large-scale expansions and replication stalling of Friedreich's ataxia GAA repeats in an experimental mammalian system

Anastasia Rastokina, Jorge Cebrián, Negin Mozafari, Nicholas H Mandel, C I Edvard Smith, Massimo Lopes, Rula Zain, Sergei M. Mirkin

This study develops an experimental system to analyze GAA repeat expansions and replication fork stalling in human cells, finding that repeat expansions depend on proteins involved in replication fork stalling and restart.

Nucleic Acids Research · May 22, 2023Peer-reviewedGenetics