Sarah N. Wright

The paper shows common and rare genetic variants converge on shared molecular networks for most human traits, influenced by heritability and tissue specificity.

This paper identifies six PD subgroups based on cell-type-specific genetic networks and links NRG6 to reduced myelin integrity in oligodendrocytes.

This paper introduces MutationProjector, an AI model that converts tumor mutation profiles into cancer subtype representations, achieving strong performance in predicting treatment responses and classifying metastasis.

The paper evaluates 46 human interactomes to identify which are best for disease gene discovery and interaction prediction, finding large networks like HumanNet perform better for disease genes while smaller ones like DIP excel in prediction.