Ingoo Lee

Redefining Parkinson's Disease by Dysregulated Genetic Networks in Distinct Cell Types

This paper identifies six PD subgroups based on cell-type-specific genetic networks and links NRG6 to reduced myelin integrity in oligodendrocytes.

Translating clinical gene sequencing into a foundational representation of tumor subtype

This paper introduces MutationProjector, an AI model that converts tumor mutation profiles into cancer subtype representations, achieving strong performance in predicting treatment responses and classifying metastasis.

A genotype-phenotype transformer to assess and explain polygenic risk

This paper introduces a Transformer model called G2PT to predict metabolic traits from genetic variants and shows it outperforms existing methods across populations.