The paper evaluates a scalable approach using scRNA-seq to generate cell-type specific transcriptomic profiles of mesenchymal lineage cells from mouse bone marrow-derived stromal cells.

DOI 10.1101/2022.12.13.520148

mousescRNA-seq

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GenomicsNature GeneticsPeer-reviewedMay 19, 2022

Cell-specific chromatin landscape of human coronary artery resolves regulatory mechanisms of disease risk

Adam W. Turner, Shengen Shawn Hu, José Verdezoto Mosquera…·Clint L. Miller

The paper uses single-cell ATAC-seq to analyze coronary artery cells from CAD patients, identifying regulatory mechanisms and risk variants associated with disease.

159 citationstop 1%

humanscATAC-seq

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GeneticsNature GeneticsPeer-reviewedJun 14, 2021

Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes

Catherine C. Robertson, Jamie R. J. Inshaw, Suna Önengüt-Gümüşcü…·Stephen S. Rich

This study identifies causal variants, cells, genes, and drug targets for type 1 diabetes using large-scale genetic and functional genomic analyses.

302 citationstop 1%

humanGWAS summary statistics

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GeneticsNature CommunicationsPeer-reviewedJun 7, 2021

Systems genetics analyses in Diversity Outbred mice inform human bone mineral density GWAS and identify Qsox1 as a novel determinant of bone strength

Basel Maher Al-Barghouthi, Larry D. Mesner, Gina M. Calabrese…·Charles R. Farber

The paper uses Diversity Outbred mice to analyze bone traits and identify novel genes associated with bone strength, informing human GWAS findings.

53 citationstop 1%

mousebulk RNA-seq

𝕏 PostBluesky