Author

Akbar Ali

University of Massachusetts Chan Medical SchoolORCID 0000-0003-3491-791XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 1 Approach:machine learning (classical)· 1 Assay:metabolomics· 1 Organism:mouse· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

Celia A. SchifferiD· 2 shared E.A. NalivaikaiD· 2 shared K. KosovrastiiD· 2 shared M. HenesiD· 2 shared Neşe Kurt YılmaziD· 2 shared Ala M. ShaqraiD· 1 shared Florian LeidneriD· 1 shared G.J. LockbaumiD· 1 shared

Activity by Year

2018-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersBiophysics

Celia A. SchifferORCID

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3 papers

Recent·Most cited

BiophysicsbioRxivPreprintOct 1, 2026

A Dynamics-Informed Machine Learning Framework for Inhibitor Optimization Against Quickly Evolving Targets to Avoid Resistance

Lauren E. Intravaia, Jagroop Kaur, Ala M. Shaqra…·Celia A. Schiffer

This paper introduces ROBUST, a machine learning framework that identifies energetic determinants of inhibitor potency against evolving targets, demonstrating its utility in predicting and optimizing inhibitors with improved resistance profiles.

DOI 10.64898/2026.09.25.754496

protein structuremachine learning (classical)

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BiochemistryJournal of Lipid ResearchPeer-reviewedJul 9, 2026

A method to synthesize analytical rhodoquinone standards for quantitative analysis in tissue specimen

Thang Do, Akbar Ali, Jessica B. Spinelli

The paper synthesizes and purifies rhodoquinone standards for absolute quantification in mammalian tissues and ETC studies.

DOI 10.1016/j.jlr.2026.101099

mousemetabolomics

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Molecular BiologyACS Infectious DiseasesPeer-reviewedDec 13, 2018

Structural Adaptation of Darunavir Analogs Against Primary Resistance Mutations in HIV-1 Protease

G.J. Lockbaum, Florian Leidner, Linah N. Rusere…·Celia A. Schiffer

The paper investigates how structural changes in HIV-1 protease affect the potency of Darunavir and its analogs against primary resistance mutations using crystal structures and vdW interaction analysis.

37 citations

humanproteomics

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