Darren A. Walsh

Typical development of synaptic and neuronal properties can proceed without microglia in the cortex and thalamus

This study shows that neurodevelopmental processes in the cortex and thalamus can occur normally without microglia, using a genetically modified mouse model.

PV-specific loss of the transcriptional coactivator PGC-1α slows down the evolution of epileptic activity in an acute ictogenic model.

This study shows that reducing PGC-1α in PV interneurons decreases seizure-like activity in an acute epilepsy model by limiting interneuron firing intensity.

Circadian rhythm in cortical chloride homeostasis underpins variation in network excitability

The paper shows that intracellular chloride levels in cortical pyramidal cells vary diurnally, affecting neuronal network stability and seizure latency.

Characterization of light penetration through brain tissue, for optogenetic stimulation

The paper measures light penetration through rodent brain tissue using nucleated patches and direct visualization, finding a lower extinction coefficient than previous estimates.

Neurophysiological alterations in the nucleus reuniens of a mouse model of Alzheimer’s disease

The paper examines neurophysiological changes in the nucleus reuniens of J20 mice, finding hyperpolarized membrane potentials and altered rebound firing without changes in action potential generation.