Alexandra L. McAllan

Defining the Immunomodulatory Determinants of 3-mer Oligonucleotides on TLR7 and TLR8 sensing

The paper identifies how 3-mer oligonucleotides with base and sugar modifications modulate TLR7 and TLR8 responses, leading to the development of a dual inhibitory oligonucleotide for autoimmune disease.

2'-O-Methyl-guanosine 3-base RNA fragments mediate essential natural TLR7/8 antagonism

The paper identifies 2'-O-methyl-guanosine RNA fragments as natural antagonists of TLR7/8, preventing auto-immunity by inhibiting TLR signaling.

Annexin A2 mediates RIG-I-like receptor responses to viral infection

This study identifies Annexin A2 as a critical mediator of RIG-I-like receptor responses to viral infection by promoting MDA5 oligomerization and enhancing interferon production.