Irina V. Solovei

This paper identifies Ab-trapping as a staining artifact in antibody-based techniques, showing it results from high epitope abundance, high Ab affinity, and low diffusion rates, and suggests mitigation strategies.

The paper shows that genome-lamina interactions are reconfigured during limb development to prime regulatory domains for gene activation and support cell-fate decisions.

This study examines the retinal photoreceptor composition and eye features of the aardvark, finding a mix of rod and cone photoreceptors with limited color discrimination.

The paper uses microscopy to study delayed co-transcriptional splicing in the highly expressed thyroglobulin gene, finding a delay in splicing downstream of transcribed introns.

This paper investigates the mechanism of nuclear inversion in rod photoreceptors by combining Hi-C, microscopy, and polymer modeling, revealing that heterochromatin interactions drive phase separation and that lamina interactions maintain conventional nuclear organization.